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研究成果

研究成果

2013 2012 2011 2010 2009 2008 2007

 2013

  1. Human neutralizing epitope in the envelope domain II of dengue virus recognizing by dengue patients shows dynamic conformational change after fusion process.
    Yamashita, A., Kawashita, N., Li, YG, Sasaki, T., Tao, R., Yang, P., Ramasoota, P., and Ikuta, K.
    Future Virology, in press.
  2. Molecular characterization of Clostridium botulinum isolates from Foodborne Outbreaks in Thailand, 2010.
    Wangroongsarb, P., Kohda, T., Jittaprasartsin, C., Suthivarakom, K., Kamthalang, T., Umeda, K., Sawanpanyalert, P., Kozaki, S., and Ikuta, K.
    PLoS One, in press. (Pubmed)
  3. Variables influencing anti-human immunodeficiency virus type 1 neutralizing human monoclonal antibody (NhMAbI production among infected Thais.
    Akapirat, S., Avihingsanon, A., Ananworanich, J., Schuetz, A., Ramasoota, P., Luplertlop, N., Ono, K., Ikuta, K., Utachee, P., Kameoka, M., Leaungwutiwong, P.
    Sountheast Asian J. Trop. Med. Health 44: 825-841.
  4. A small compound targeting the intereaction between nonstructural proteins 2B and 3 inhibits dengue virus replication.
    Pambudi, S., Kawashita, N., Phanthanawiboon, S., Omokoko, M.D., Masrinoul, P., Limkittikul, K., Yasunaga, T., Takagi, T., Ikuta, K., and Kurosu, T.
    Biochem. Biophy. Res. Commun., in press. (Pubmed)
  5. Emerging antigenic variants at the antigenic site Sb in pandemic (H1N1) 2009 influenza virus in Japan detected by a human monoclonal antibody.
    Yasugi, M., Kubota-Koketsu, R., Yamashita, A., Kawashita, N., Du, A., Misaki, R., Kuhara, M., Boonsathorn, N., Fujiyama, K., Okuno, Y., Nakaya, T., and Ikuta, K.
    PLoS One, 8(10), e77892, 2013 (Pubmed)
  6. Cross-reactivity of human monoclonal antibodies generated with peripheral blood lymphocytes from dengue patients with Japanese encephalitis virus.
    Pipatthanaboon, C., Sasaki, T., Nishimura, M., Setthapramote, C., Pitaksajjakul, P., Leuangwutiwong, P., Limkittikul, K., Puiprom, O., Sasayama, M., Chaichana, P., Okabayashi, T., Kurosu, T., Ramasoota, P., and Ikuta, K.
    Biologics 7: 175-187, 2013. (Pubmed)
  7. N2 gas plasma inactivates influenza virus by inducing changes in viral surface morphology, protein and genomic RNA.
    Sakudo, A., Shimuzu, N., Imanishi, Y., and Ikuta, K.
    BioMed. Res. Int., in press.
  8. Detection and characterization of enteric viruses in flood water from the 2011 Thai flood.
    Ngaosuwankul, N., Thippornchai, N., Morales Vargas, E., Tunyong, W., Mahakunkijchareon, Y., Ikuta, K., Singhasivanon, P., Okabayashi, T., and Leaungwutiwong, P.
    Jpn. J. Infect. Dis. 66: 398-403, 2013. (Pubmed)
  9. Proteolysis of abonormal prion protein with a thermostable protease from Termococcus kodakarensis KODI.
    Koga, Y., Tanaka, S., Sakudo, A., Tobiume, M., Aranishi, M., Hirata, A., Takano, K., Ikuta, K., and Kanaya, S.
    Appl. Microbiol. Biotechnol., in press.
  10. Enzymatic activity of a subtilisin homolog, Tk-SP, from Thermococcus kodakarensis in detergents and its ability to degrade the abnormal prion protein.
    Hirata, A., Hori, Y., Koga, Y., Okada, J., Sakudo, A., Ikuta, K., Kanaya, S., and Takano, K.
    BMC Biotechnology 13:19, 2013. (Pubmed)
  11. Immunization of Rabbits with Synthetic Peptides Derived from a Highly Conserved β-Sheet Epitope Region Underneath the Receptor Binding Site of Influenza A Virus.
    Ideno S, Sakai K, Yunoki M, Kubota-Koketsu R, Inoue Y, Nakamura S, Yasunaga T, Okuno Y, Ikuta K.
    Biologics: Targets and Therapy, Epub 2013 Nov 5. (Pubmed)
  12. Misinterpretation in virus clearance studies of biological products due to an uncommon discrepancy between cytopathic effects and infectivity of human immunodeficiency virus (HIV).
    Urayama T, Cameron R, Sato T, Yunoki M, Ikuta K
    Biologicals. 2013 Mar;41(2):125-7 (Pubmed)
  13. Human monoclonal antibodies broadly neutralizing against influenza B virus.
    Yasugi, M., Kubota-Koketsu, R., Yamashita, A., Kawashita, N., Du, A., Sasaki, T., Nishimura, M., Misaki, R., Kuhara, M., Boonsathorn, N., Fujiyama, K., Okuno, Y., Nakaya, T., and Ikuta, K.
    PLoS Pathog. 9, e1003150, 2013. (Pubmed)
  14. Antiviral protein of Momordica Charantia Linn inhibits different subtypes of influenza A.
    Pongthanapisith V, Ikuta K, Puttawatana P, Leelamanit W.
    Evid Based Complement Alternat Med. Epub 2013 Jul 9. (Pubmed).
  15. Evolution and control of H5N1. A better understanding of the evolution and diversity of H5N1 flu virus and its host species in endemic areas could inform more efficient vaccination and control strategies.
    Watanabe Y, Ibrahim MS, Ikuta K.
    EMBO Rep. 2013 Feb;14(2):117-22. (Pubmed)
  16. Discovery of novel low-molecular-weight HIV-1 inhibitors interacting with cyclophilin A using in silico screening and biological evaluations.
    Tian YS, Verathamjamras C, Kawashita N, Okamoto K, Yasunaga T, Ikuta K, Kameoka M, Takagi T.
    J Mol Model. 2013 Jan;19(1):465-75.(Pubmed)
  17. Chikungunya virus induces a more moderate cytopathic effect in mosquito cells than in mammalian cells.
    Li YG, Siripanyaphinyo U, Tumkosit U, Noranate N, A-nuegoonpipat A, Tao R, Kurosu T, Ikuta K, Takeda N, Anantapreecha S.
    Intervirology. 2013;56(1):6-12. (Pubmed)
  18. Dengue virus neutralization and antibody-dependent enhancement activities of human monoclonal antibodies derived from dengue patients at acute phase of secondary infection.
    Sasaki T, Setthapramote C, Kurosu T, Nishimura M, Asai A, Omokoko MD, Pipattanaboon C, Pitaksajjakul P, Limkittikul K, Subchareon A, Chaichana P, Okabayashi T, Hirai I, Leaungwutiwong P, Misaki R, Fujiyama K, Ono K, Okuno Y, Ramasoota P, Ikuta K.
    Antiviral Res. 2013 Jun;98(3):423-31. (Pubmed)feature
  19. Characterization of chikungunya virus infection of a human keratinocyte cell line: Role of mosquito salivary gland protein in suppressing the host immune response.
    Puiprom O, Morales Vargas RE, Potiwat R, Chaichana P, Ikuta K, Ramasoota P, Okabayashi T.
    Infect. Genet. Evol. 17, 210-215, 2013. (Pubmed)
  20. Enzymatic activity of a subtilisin homolog, Tk-SP, from Thermococcus kodakararensis in detergents and its ability to degrade the abnormal prion protein.
    Hirata A., Hori Y, Koga Y, Okada J, Sakudo, A, Ikuta K, Kanaya S, Takano K.
    BMC Biotechnology 13, 19, 2013 (Pubmed)
  21. Induction of Anti-Influenza Immunity by Modified Green Fluorescent Protein (GFP) Carrying Hemagglutinin-derived Epitope Structure.
    Yuji Inoue, Ritsuko Kubota-Koketsu, Akifumi Yamashita, Mitsuhiro Nishimura, Shoji Ideno, Ken-ichiro Ono, Yoshinobu Okuno and Kazuyoshi Ikuta
    J. Biol. Chem., 288(7), pp. 4981-4990, 2013. (Pubmed)feature
  22. Jurkat cell proliferation is suppressed by Chlamydia (Chlamydophila) pneumoniae infection accompanied with attenuation of phosphorylation at Thr389 of host cellular p70S6K.
    Hirai I, Ebara M, Nakanishi S, Yamamoto C, Sasaki T, Ikuta K, Yamamoto Y.
    Immunobiology. 2013 Apr;218(4):527-32. (Pubmed)
pagetoppagetop

 2012

  1. Reliability of a newly-developed immunochromatography diagnostic kit for pandemic influenza A/H1N1pdm virus: implications for drug administration.
    Sasaki T, Kubota-Koketsu R, Takei M, Hagihara T, Iwamoto S, Murao T, Sawami K, Fukae D, Nakamura M, Nagata E, Kawakami A, Mitsubayashi Y, Ohno M, Uehara Y, Fukukawa T, Kanai Y, Kosaka M, Ikuta K.
    PLoS One. 2012;7(11):e50670. (Pubmed)
  2. Frequency of D222G and Q223R hemagglutinin mutants of pandemic (H1N1) 2009 influenza virus in Japan between 2009 and 2010.
    Yasugi M, Nakamura S, Daidoji T, Kawashita N, Ramadhany R, Yang CS, Yasunaga T, Iida T, Horii T, Ikuta K, Takahashi K, Nakaya T.
    PLoS One. 2012;7(2):e30946. (Pubmed)
  3. Human monoclonal antibodies to neutralize all dengue virus serotypes using lymphocytes from patients at acute phase of the secondary infection.
    Setthapramote C, Sasaki T, Puiprom O, Limkittikul K, Pitaksajjakul P, Pipattanaboon C, Sasayama M, Leuangwutiwong P, Phumratanaprapin W, Chamnachanan S, Kusolsuk T, Jittmittraphap A, Asai A, Arias JF, Hirai I, Kuhara M, Okuno Y, Kurosu T, Ramasoota P, Ikuta K.
    Biochem Biophys Res Commun. 2012 Jul 13;423(4):867-72. (Pubmed)
  4. A technique for capturing broad subtypes and circulating recombinant forms of HIV-1 based on anionic polymer-coated magnetic beads.
    Sakudo A, Ikuta K.
    Int J Mol Med. 2012 Aug;30(2):437-42. (Pubmed)
  5. Bornavirus closely associates and segregates with host chromosomes to ensure persistent intranuclear infection.
    Matsumoto Y, Hayashi Y, Omori H, Honda T, Daito T, Horie M, Ikuta K, Fujino K, Nakamura S, Schneider U, Chase G, Yoshimori T, Schwemmle M, Tomonaga K.
    Cell Host Microbe. 2012 May 17;11(5):492-503. (Pubmed)
  6. Visible and near-infrared spectra collected from the thumbs of patients with chronic fatigue syndrome for diagnosis.
    Sakudo A, Kuratsune H, Kato YH, Ikuta K.
    Clin Chim Acta. 2012 Oct 9;413(19-20):1629-32. (Pubmed)
  7. Tropism of Pandemic 2009 H1N1 Influenza a Virus.
    Ramadhany R, Yasugi M, Nakamura S, Daidoji T, Watanabe Y, Takahashi K, Ikuta K, Nakaya T.
    Front Microbiol. 2012 Apr 4;3:128. (Pubmed)
  8. Neutralization titers against influenza A (H3N2) and influenza B viruses among a non-vaccinated population from Thailand.
    Boonsathorn N, Kanai Y, Punjumpa J, Bai G, Chittaganpitch M, Petphuwadee U, Jampangern W, Sawanpanyalert P, Ikuta K, Teerasut C.
    Southeast Asian J Trop Med Public Health. 2012 May;43(3):674-9. (Pubmed)
  9. Hepatitis E virus in Norway rats (Rattus norvegicus) captured around a pig farm.
    Kanai Y, Miyasaka S, Uyama S, Kawami S, Kato-Mori Y, Tsujikawa M, Yunoki M, Nishiyama S, Ikuta K, Hagiwara K.
    BMC Res Notes. 2012 Jan 5;5:4. (Pubmed)
  10. Diagnosis of HIV-1 infection by near-infrared spectroscopy: analysis using molecular clones of various HIV-1 subtypes.
    Sakudo A, Suganuma Y, Sakima R, Ikuta K.
    Clin Chim Acta. 2012 Feb 18;413(3-4):467-72. (Pubmed)
  11. Variability of parvovirus B19 genotype 2 in plasma products with different compositions in the inactivation sensitivity by liquid-heating.
    Tsujikawa M, Nishigaki H, Yoshikawa M, Furuki R, Takahashi K, Adan-Kubo J, Shimamura Y, Urayama T, Hattori S, Sakai K, Yunoki M, Ikuta K.
    Vox Sang. 2012 Feb;102(2):93-9. (Pubmed)
  12. Detection of influenza virus using a lateral flow immunoassay for amplified DNA by a microfluidic RT-PCR chip.
    Nagatani N, Yamanaka K, Ushijima H, Koketsu R, Sasaki T, Ikuta K, Saito M, Miyahara T, Tamiya E.
    Analyst. 2012 Aug 7;137(15):3422-6. (Pubmed)
  13. Limited cross-reactivity of mouse monoclonal antibodies against Dengue virus capsid protein among four serotypes.
    Noda M, Masrinoul P, Punkum C, Pipattanaboon C, Ramasoota P, Setthapramote C, Sasaki T, Sasayama M, Yamashita A, Kurosu T, Ikuta K, Okabayashi T.
    Biologics. 2012;6:409-16. (Pubmed)
  14. Analysis of Vis-NIR spectra changes to measure the inflammatory response in the nasal mucosal region of influenza A and B virus-infected patients.
    Sakudo A, Baba K, Ikuta K.
    J Clin Virol. 2012 Dec;55(4):334-8. doi: 10.1016/j.jcv.2012.08.015. Epub 2012 Sep 12. (Pubmed)
  15. Significant neutralizing activities against H2N2 influenza A viruses in human intravenous immunoglobulin lots manufactured from 1993 to 2010.
    Kubota-Koketsu R, Yunoki M, Okuno Y, Ikuta K.
    Biologics. 2012;6:245-7. (Pubmed)
  16. The changing nature of avian influenza A virus (H5N1).
    Watanabe Y, Ibrahim MS, Suzuki Y, Ikuta K.
    Trends Microbiol. 2012 Jan;20(1):11-20. (Pubmed) feature
  17. Frequency of D222G and Q223R hemagglutinin mutants of pandemic (H1N1) 2009 influenza virus in Japan between 2009 and 2010.
    Yasugi M, Nakamura S, Daidoji T, Kawashita N, Ramadhany R, Yang CS, Yasunaga T, Iida T, Horii T, Ikuta K, Takahashi K, Nakaya T.
    PLoS One. 2012;7(2):e30946. (Pubmed)
  18. Antigenic analysis of highly pathogenic avian influenza virus H5N1 sublineages co-circulating in Egypt.
    Watanabe Y, Ibrahim MS, Ellakany HF, Kawashita N, Daidoji T, Takagi T, Yasunaga T, Nakaya T, Ikuta K.
    J Gen Virol. 2012 Oct;93(Pt 10):2215-26. (Pubmed)
  19. Poly (I:C), an agonist of toll-like receptor-3, inhibits replication of the Chikungunya virus in BEAS-2B cells.
    Li YG, Siripanyaphinyo U, Tumkosit U, Noranate N, A-Nuegoonpipat A, Pan Y, Kameoka M, Kurosu T, Ikuta K, Takeda N, Anantapreecha S.
    Virol J. 2012 Jun 14;9:114. (Pubmed)
  20. Discrimination of influenza virus-infected nasal fluids by Vis-NIR spectroscopy.
    Sakudo A, Baba K, Ikuta K.
    Clin Chim Acta. 2012 Dec 24;414:130-4. (Pubmed)
pagetoppagetop

 2011

  1. Dengue virus presence and surveillance in Okinawa (Review).
    Sakudo A, Onodera T, Shintani H, Ikuta K.
    Exp Ther Med. 2012 Jan;3(1):15-17.(Pubmed)
  2. Fundamentals of prions and their inactivation.
    Sakudo A, Ano Y, Onodera T, Nitta K, Shintani H, Ikuta K, Tanaka Y.
    Int. J. Mol. Med. 27, 483-489, 2011. (Pubmed)
  3. Co-existence of major and minor viral populations from two different origins in patients secondarily infected with dengue virus serotype 2 in Bangkok.
    Puiprom, O., Yamashita, A., Sasayama, M., Limkittikul, K., Jittmitraphap, A., Leaungwutiwong, P., Kurosu, T., Ramasoota, P., and Ikuta, K.
    Biochem Biophys Res Commun. 2011 Sep 16;413(1):136-42. doi: 10.1016/j.bbrc.2011.08.069. Epub 2011 Aug 22. (Pubmed)
  4. Molecular evolution of HIV-1 CRF01_AE Env in Thai patients.
    Boonchawalit, S., Jullaksorn, D., Uttiyoung, J., Yowang, A., Krathong, N., Chautrakul, S., Yamashita, A., Ikuta, K., Roobsoong, A., Kanitvittaya, S., Sawanpanyalert, P., and Kameoka, M.
    PLoS One 6, e27098, 2011. (Pubmed)
  5. Semi-real time electrochemical monitoring for influenza virus RNA by reverser transcription loop-mediated isothermal amplification using a USB powered portable potentiostat.
    Nagatani, N., Yamanaka, K., Saito, M., Koketsu, R., Sasaki, T., Ikuta, K., Miyahara, T., and Tamiya, E.
    Analyst 135, 5143-5150, 2011. (Pubmed)
  6. Caution in evaluation of removal of virus by filtration: Misinterpretation due to detection of viral genome fragments by PCR.
    Tsujikawa, M., Ohkubo Y., Masuda, M., Tanaka, H., Takahashi, K., Sasaki, Y., Yunoki, M., and Ikuta, K.
    J. Virol. Methods 178, 39-43, 2011. (Pubmed)
  7. Capture of dengue virus type 3 using anionic polymer-coated magnetic beads.
    Sakudo, K., Masrinoul, P., Tanaka, Y., and Ikuta, K.
    Int. J. Mol. Med. 28, 625-628, 2011. (Pubmed)
  8. Viral factors involved in adaptor-related protein complex 2 alpha 1 subunit-mediated regulation of human immunodeficiency virus type 1 replication.
    Sapsutthipas, S., Kitagawa, Y., Tokunaga, K., Ikuta, K., and Kameoka, M.
    Southeastern Asian J. Trop. Med. Public Health 42, 311-319, 2011.
  9. Genetic diversification of H5N1 highly pathogenic avian influenza A virus during replication in wild ducks.
    Watanabe, Y., Ibrahim, M. S., Ellakany, H. F., Abd El-Hamid, H. S., and Ikuta, K.
    J. Gen. Virol. 92, 2105-2110, 2011.
  10. Highly conserved region 141-168 of the NS1 protein is a new common epitope region of dengue virus.
    Jpn. J. Infect. Dis., 64, 109-115, 2011.
    Masrinoul, P., Diata, M. O., Pambudi, S., Limkittikul, K., Ikuta, K., and Kurosu, T.
  11. Analysis of intracellular distribution of Borna disease virus glycoprotein fused with fluorescent markers in living cells.
    Daito, T., Fujino, K., Watanabe, Y., Ikuta, K., and Tomonaga, K.
    J. Vet. Med. Sci. 73, 1243-1247, 2011.
  12. Acquisition of human-type receptor binding specificity by new H5N1 influenza virus sublineages during their emergence in birds in Egypt.
    Watanabe, Y., Ibrahim, M.S., Ellakany, H.F., Kawashita, N., Mizuike, R., Hiramatsu, H., Sriwilaijaroen, N., Takagi, T., Suzuki, Y., and Ikuta, K.
    PLoS Pathog. 7, e1002068, 2011. (Pubmed) feature
  13. Rapid detection for primary screening of influenza A virus: microfluidic RT-PCR chip and electrochemical DNA sensor.
    Analyst 136, 2064-2068, 2011.
    Yamanaka, K., Saito, M., Kondoh, K., Hossain, M.M., Koketsu, R., Sasaki, T., Nagatani, N., Ikuta K., and Tamiya, E.
  14. Capture of infectious borna disease virus using anionic polymer-coated magnetic beads.
    Sakudo, A., Tanaka, Y., and Ikuta, K.
    Neurosci. Lett. 494, 237-239, 2011.
  15. Development of two types of rapid diagnostic test kits to detect the hemagglutinin or nucleoprotein of the swine-origin pandemic influenza A virus H1N1.
    Mizuike, R., Sasaki, T., Baba, K., Iwamoto, H., Shibai, Y., Kosaka, M., Kubota-Koketsu, R., Yang, C.-S., Du, A., Sakudo, A., Tsujikawa, M., Yunoki, M., and Ikuta, K.
    Clin. Vaccine Immunol. 18, 494-499, 2011. (Pubmed) feature
  16. Yeast prion protein New1 can break Sup35 amyloid fibrils into fragments in an ATP-dependent manner.
    Inoue Y, Kawai-Noma S, Koike-Takeshita A, Taguchi H, Yoshida M.
    Genes Cells. 2011 May;16(5):545-56. (Pubmed)
  17. Host-specific genetic variation of highly pathogenic avian influenza viruses (H5N1).
    Ibrahim, M.S. Watanabae, Y., Ellakany, H.F., Yamagishi, A., Sapsutthipas, S., Toyoda, T., Abd El-Hamied, H. S., and Ikuta, K.
    Virus Genes 42, 363-368, 2011. (Pubmed)
pagetoppagetop

 2010

 
  1. Immunofluorescence assay in India for confirmation of HIV-1 infection using a T-cell line infected with defective HIV-1. Int. J.
    Bala, M,. Arias, J.F., Deb, M., and Ikuta, K.
    Infect. Dis. 14, e1093-1098, 2010(Pubmed)
  2. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus.
    Kayamuro, H., Yoshioka, Y., Abe, Y., Arita, S., Katayama, K., Nomura, T., Yoshikawa, T., Kubota-Koketsu, R., Ikuta, K., Okamoto, S., Mori, Y., Kunisawa, J., Kiyono, H., Itoh, Y., Nagano, K., Kamada, H., Tsutsumi, Y., and Tsunoda, S.
    J. Virol. 84, 12703-12712, 2010.(Pubmed)
  3. Appearance of Drug Resistance-Associated Mutations in Human Immunodeficiency Virus Type 1 CRF01_AE Integrase Derived from Drug-Naive Thai Patients.
    Isarangkura-Na-Ayuthaya, P., Kaewnoo, W., Auwani,t W., de Silva, U.C., Ikuta, K., Sawanpanyalert, P., and Kameoka, M.
    AIDS Res. Hum. Retroviruses 26, 1341-1323, 2010.(Pubmed)
  4. Distinct propagation efficiencies of H5N1 influenza virus Thai isolates in newly established murine respiratory region-derived cell clones.
    Kanai, Y., Chittaganpitch, M., Nakamura, I., Li, G.M., Bai, G.R., Li, Y.G., Ikuta, K., and Sawanpanyalert, P.
    Virus Res. 153, 218-225, 2010. (Pubmed)
  5. Design and evaluation of antiretroviral peptides corresponding to the C-terminal heptad repeat region (C-HR) of human immunodeficiency virus type 1 envelope glycoprotein gp41.
    Soonthornsata, B., Tian, Y.S., Utachee, P., Sapsutthipas, S., Isarangkura-na-Ayuthaya, P., Auwanit, W., Takagi, T., Ikuta, K., Sawanpanyalert, P., Kawashita, N., and Kameoka, M.
    Virology 405, 157-164, 2010. (Pubmed)
  6. Fab MAbs specific to HA of influenza virus with H5N1 neutralizing activity selected from immunized chicken phage library.
    Pitaksajjakul, P., Lekcharoensuk, P., Uparagarin, N., Barbas, C.F., 3rd., Ibrahim, M.S., Ikuta, K., and Ramasoota, P.
    Biochem. Biopys. Res. Commun. 395, 496-501, 2010.(Pubmed)
  7. The impact of antigenic drift of influenza A virus on human herd immunity: Sero-epidemiological study of H1N1 in healthy Thai population in 2009.
    Kanai, Y., Boonsathorn, N., Chittaganpitch, M., Bai, G., Li, Y., Kase, T., Takahashi, K., Okuno, Y., Jampangern, W., Ikuta, K., and Sawanpanyalert, P.
    Vaccine 28, 5437-5444, 2010.(Pubmed)
  8. The role of lysine residue at amino acid position 165 of human immunodeficiency virus type 1 CRF01_AE Gag in reducing viral drug susceptibility to protease inhibitors.
    Kameoka, M., Isarangkura-na-Ayuthaya, P., Kameoka, Y., Sapsutthipas, S., Soonthornsata, B., Nakamura, S., Tokunaga, K., Sawanpanyalert, P., Ikuta, K., and Auwanit, W.
    Virology 405, 129-138, 2010.(Pubmed)
  9. Long-term shedding of hepatitis E virus in the feces of pigs infected naturally, born to sows with and without maternal antibodies.
    Kanai, Y., Tsujikawa, M., Yunoki, M., Nishiyama, S., Ikuta, K., and Hagiwara, K.
    J. Med. Virol. 82, 69-76, 2010.(Pubmed)
  10. Characterization of H5N1 influenza viruses isolated from humans in vitro.
    Y.G., Chittaganpitch, M., Waicharoen, S., Kanai, Y., Bai, G.R., Kameoka, M., Takeda, N., Ikuta, K., and Sawanpanyalert, P.
    Virological J. 7, 112, 2010.(Pubmed)
  11. Molecular detection of genotype 3 porcine hepatitis E virus in aborted fetuses and their sows.
    Arch. Virol. 155, 1157-1161, 2010.
    Hosmillo, M., Jeong, Y.J., Kim, H.J., Park, J.G., Nayak, M.K., Alfajaro, M.M., Collantes, T.M., Park, S.J., Ikuta, K., Yunoki, M., Kang, M.I., Park, S.I., and Cho, K.O.
  12. Distinct propagation efficiencies of H5N1 influenza virus Thai isolates in newly established murine respiratory region-derived cell clones.
    Kanai, Y., Chittaganpitch, M., Nakamura, I., Li, G., Bai, G., Li, Y., Ikuta, K., and Sawanpanyalert, P.
    Virus Res. 153, 218-225, 2010.
  13. Full-length sequences of one genotype 4 and three genotype 3 hepatitis E viruses in fecal samples from domestic swine in Japan.
    Urayama, T., Sapsutthipas, S., Tsujikawa, M., Yamashita, A., Nishigaki, H., Ibrahim, M.S., Hagiwara, K., Yunoki, M., Yasunaga, T., Yamaguchi, T., and Ikuta, K..
    OpenVet. 4, 11-19, 2010.
  14. Highly efficient rescue of dengue virus using a co-culture system with mosquito/mammalian cells.
    Kurosu T, Khamlert C, Phanthanawiboon S, Ikuta K, Anantapreecha S.
    Biochem. Biophys. Res. Commun. 394, 398-404, 2010.(Pubmed)
  15. High systemic levels of interleukin-10, interleukin-22 and C-reactive protein in Indian patients are associated with low in vitro replication of HIV-1 subtype C viruses.
    Arias, J.F., Nishihara, R., Bala, M., and Ikuta, K.
    Retrovirology 7, 15, 2010.(Pubmed)
  16. Two N-linked glycosylation sites in V2 and C2 regions of human immunodeficiency virus type 1 CRF01_AE envelope glycoprotein gp120 regulate viral neutralization susceptibility to the human monoclonal antibody specific for CD4 binding domain.
    Utachee, P., Nakamura, S., Israngkura-Na-Ayuthaya, P., Tokunaga, K., Sawanpanyalert, P., Ikuta, K., Auwanit, W., and Kameoka, M.
    J. Virol. 84, 4311-4320, 2010.(Pubmed)
  17. Highly conserved sequences for human neutralization epitope on hemagglutinin of influenza A viruses H3N2, H1N1 and H5N1: Implication for human monoclonal antibody recognition.
    Yamashita, A., Kawashita, N., Kubota-Koketsu, R., Inoue, Y., Watanabe, Y., Ibrahim, M.S., Ideno, S., Yunoki, M., Okuno, Y., Takagi, T., Yasunaga, T., and Ikuta, K.
    Biochem. Biophys. Res. Commun. 393, 614-618, 2010.(Pubmed)
  18. Endogenous non-retroviral RNA virus elements in mammalian genomes.
    Horie, M., Honda, T., Suzuki, Y., Kobayashi, Y., Daito, T., Oshida, T.,Ikuta, K., Jem, P., Gojobori, T., Coffin, J. M., and Tomonaga, K.
    Nature 463, 84-87, 2010.(Pubmed)
  19. Highly pathogenic H5N1 avian influenza virus induces extracellular Ca2+ influx, leading to apoptosis in avian cells.
    Ueda, M., Daidoji, T., Du, A., Yang, C.S., Ibrahim, M.S., Ikuta, K., and Nakaya, T.
    J. Virol. 84, 3068-3078, 2010.(Pubmed)
  20. Infectious prion protein in the filtrate even after 15 nm filtration.
    Yunoki, M., Tanaka, H., Urayama, T., Kanai, Y., Nishida, A., Yoshikawa, M., Ohkubo, Y., Kawabata, Y., Hagiwara, K., and Ikuta, K.
    Biologicals 38, 311-313, 2010.(Pubmed)
  21. Genotypic characterization of HIV-1 env gp160 sequences from three regions in Thailand.
    de Silva, U.C., Warachit, J., Sattagowit, N., Jirapongwattana, C., Panthong, S., Utachee, P., Yasunaga, T., Ikuta, K., Kameoka, M., and Boonsathorn, N.
    AIDS Res. Hum. Retroviruses 26, 223-227, 2010.(Pubmed)
  22. Structure of the prion protein and its gene: an analysis using bioinformatics and computer simulation (Review).
    Sakudo, A., Xue, G., Kawashita, N., Ano, Y., Takagi, T., Shintani, H., Tanaka, Y., Onodera, T., and Ikuta, K.
    Curr. Protein Pept. Sci. 11, 166-179, 2010.(Pubmed)
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 2009

  1. Autogenous translational regulation of the Borna disease virus negative control factor X from polycistronic mRNA using host RNA helicases.
    Watanabe, Y., Ohtaki, N., Hayashi, Y., Ikuta, K., and Tomonaga, K.
    PLoS Pathol. E1000654, 2009.
  2. Amantadine- and oseltamivir-resistant variants of influenza A viruses in Thailand.
    Bai, G.-R., Chittaganpitch, M., Kanai, Y., Li, Y.-G., Auwanit, W., Ikuta, K., and Sawanpanyalert, P.
    Biochem. Biophys. Res. Commun. 390, 897-901, 2009.
  3. Sequence variation in hepatitis E virus genotypes 3 and 4 from swine fecal samples in Japan.
    Sapsutthipas, S., Urayama, T., Yamate, M., Tsujikawa, M., Nishigaki, H., Hagiwara, K., Yunoki, M., Yasue, H., Sato, K., and Ikuta, K.
    Open Vet. Sci. J. 3, 68-75, 2009.
  4. Heat shock cognate protein 70 controls Borna disease virus replication via interaction with the viral non-structural protein X.
    Hayashi, Y., Horie, M., Daito, T., Honda, T., Ikuta, K., and Tomonaga K.
    Microbes Infect. 11, 394-402, 2009.
  5. Detection of drug resistance-associated and background mutations in human immunodeficiency virus type 1 CRF01_AE protease and reverse transcriptase derived from drug treatment-naive patients residing in central Thailand.
    Auwanit, W., Isarangkura-Na-Ayuthaya, P., Kasornpikul, D., Ikuta, K., Sawanpanyalert, P., and Kameoka, M.
    AIDS Res. Hum. Retroviruses 25, 625-631, 2009.
  6. Use of anionic polymer, poly(methyl vinyl ether-maleic anhydride)-coated beads for capture of respiratory syncytial virus.
    Sakudo, A., Baba, K., Tsukamoto, M., and Ikuta, K.
    Boorg. Med. Chem. Lett. 19, 4488-4491, 2009.
  7. Broad neutralizing human monoclonal antibodies against influenza virus from vaccinated healthy donors.
    Kubota-Koketsu, R., Mizuta, H., Oshita, M., Ideno, S., Yunoki, M., Kuhara, M., Yamamoto, N., Okuno, Y., and Ikuta, K.
    Biochem. Biophys. Res. Commun. 387, 180-185, 2009.(Pubmed)
  8. Non-invasive prediction of hematocrit levels by portable visible and near-infrared spectrophotometer.
    Sakudo, A., Kato, Y.H., Kuratsune, H., and Ikuta, K.
    Clin. Chim. Acta 408, 123-127, 2009.
  9. Impact of amino acid variations in Gag and Protease of human immunodeficiency virus type 1 CRF01_AE strains on drug susceptibility of virus to protease inhibitors.
    Jinnopat, P., Isarangkura-Na-Ayuthaya, P., Utachee, P., Kitagawa, Y., de Silva, U.C., Siripanyaphinyo, U., Kameoka, Y., Tokunaga, K., Sawanpanyalert, P., Ikuta, K., Auwanit, W., and Kameoka, M.
    J. Acquir. Immune Defic. Syndr. 52, 320-328, 2009.
  10. Visible and near-infrared spectral changes in the thumb of patients with chronic fatigue syndrome.
    Sakudo, A., Kato, Y.H., Tajima, S., Kuratsune, H., and Ikuta, K.
    Clin. Chim. Acta, 403, 163-166, 2009.
  11. Full-length sequence of genotype 3 hepatitis E virus derived from a pig in Thailand.
    Siripanyaphinyo, U., Laohasinnarong, D., Siripanee, J., Kaeoket, K., Kameoka, M., Ikuta, K., and Sawanpanyalert, P.
    J. Med. Virol. 81, 657-664, 2009.
  12. No apparent difference in the prevalence of parvovirus B19 infection between chronic fatigue syndrome patients and healthy controls in Japan.
    Kato, Y.H., Yamate, M., Tsujikawa, M., Nishigaki, H., Tanaka, Y., Yunoki, M., Kuratsune, H., Watanabe, Y., and Ikuta, K.
    J. Clin. Virol. 44, 246-247, 2009.
  13. RNA interference directed against Axin1 upregulates human immunodeficiency virus type 1 gene expression by activating the Wnt signaling pathway in HeLa-derived J111 cells.
    Kameoka, M., Kameoka, Y., Utachee, P., Kurosu, T., Sawanpanyalert, P., Ikuta, K., and Auwanit, W.
    AIDS Res. Hum. Retroviruses 25, 1005-1011, 2009.
  14. Direct metagenomic detection of viral pathogens in nasal and fecal specimens using an unbiased high-throughput sequencing approach.
    Nakamura, S., Yang, C.S., Sakon, N., Ueda, M., Tougan, T., Yamashita, A., Goto, N., Takahashi, K., Yasunaga, T., Ikuta, K., Mizutani, T., Okamoto, Y., Tagami, M., Morita, R., Maeda, N., Kawai, J., Hayashizaki, Y., Nagai, Y., Horii, T., Iida, T., and Nakaya, T.
    PLoS One 4, e4219, 2009.
  15. Secondary structural changes of proteins in fingernails of chronic fatigue syndrome patients from Fourier-transform infrared spectra.
    Sakudo, A., Kuratsune, H., Kato, Y.H., and Ikuta, K.
    Clin. Chim. Acta 402, 75-78, 2009.
  16. Phenotypic studies on recombinant human immunodeficiency virus type 1 (HIV-1) containing CRF01_AE env gene derived from HIV-1-infected patient, residing central Thailand.
    Utachee, P., Jinnopat, P., Isarangkura-Na-Ayuthaya, P., de Silva, U.C., Nakamura, S., Siripanyaphinyo, U., Wichukchinda, N., Tokunaga, K., Yasunaga, T., Sawanpanyalert, P., Ikuta, K., Auwanit, W., and Kameoka, M.
    Microbes Infect. 11, 2334-343, 2009.
  17. Genotypic characterization of CRF01_AE env genes derived from human immunodeficiency virus type 1-infected patients residing in central Thailand.
    Utachee, P., Jinnopat, P., Isarangkura-Na-Ayuthaya, P., de Silva, U.C., Nakamura, S., Siripanyaphinyo, U., Wichukchinda, N., Tokunaga, K., Yasunaga, T., Sawanpanyalert, P., Ikuta, K., Auwanit, W., and Kameoka, M.
    AIDS Res. Hum. Retroviruses 25, 229-236, 2009.
  18. Portable visible and near-infrared spectrophotometer for triglyceride measurements.
    Kobayashi, T., Kato, Y.H., Tsukamoto, M., Ikuta, K., and Sakudo, A.
    Int. J. Mol. Med. 23, 75-79, 2009.
  19. Anionic polymer, poly(methyl vinyl ether-maleic anhydride)-coated beads-based capture of human influenza A and B virus.
    Sakudo, A., Baba, K., Tsukamoto, M., Sugimoto, A., Okada, T., Kobayashi, T., Kawashita, N., Takagi, T., and Ikuta, K.
    Bioorg. Med. Chem. 17, 752-757, 2009.
  20. Detection of circulating Asian H5N1 viruses by a newly established monoclonal antibody.
    Du, A., Daidoji, T., Koma, T., Ibrahim, M.S., Nakamura, S., de Silva, U.C., Ueda, M., Yang, C.S., Yasunaga, T., Ikuta, K., and Nakaya, T.
    Biochem. Biophys. Res. Commun. 378, 197-202, 2009.
  21. The effects of trichostatin A on the oncolytic ability of herpes simplex virus for oral squamous cell carcinoma cells.
    Katsura, T., Iwai, S., Ota, Y., Shimizu, H., Ikuta, K., and Yura, Y.
    Cancer Gene Ther. 16, 237-245, 2009.
  22. Fundamentals of prion diseases and their involvement in the loss of function of cellular prion protein (Review).
    Sakudo, A., and Ikuta, K.
    Protein Pept. Lett. 16, 217-229, 2009.
  23. Prion protein functions and dysfunction in prion diseases.
    Sakudo, A., and Ikuta, K.
    Curr. Med. Chem. 16, 380-389, 2009.
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 2008

  1. Establishment of a new glial cell line from hippocampus of prion protein gene-deficient mice.
    Nishimura, T., Sakudo, A., Xue, G., Ikuta, K., Yukawa, M., Sugiura, K., and Onodera, T.
    Biochem. Biophys. Res. Commun. 377, 1047-1050, 2008.
  2. Efficient capture of infectious H5 avian influenza virus utilizing magnetic beads coated with anionic polymer.
    Sakudo, A., and Ikuta, K.
    Biochem. Biophys. Res. Commun. 377, 85-88, 2008.
  3. H5N1 avian influenza virus induces apoptotic cell death in mammalian airway epithelial cell.
    Daidoji, T., Koma, T., Du, A., Yang, C.S., Ueda, M., Ikuta, K., and Nakaya, T.
    J. Virol. 82, 11294-11307, 2008.
  4. Ribavirin inhibits Borna disease virus proliferation and fatal neurological diseases in neonatally infected gerbils.
    Lee, B.J., Matsunaga, H., Ikuta, K., and Tomonaga K.
    Antiviral Res. 80, 380-384, 2008.
  5. Visible and near-infrared spectral changes in plasma of psychiatric patients.
    Kato, Y.H., Matsunaga, H., Sakudo, A., and Ikuta, K.
    Int. J. Mol. Med. 22, 11516-11525, 2008.
  6. IIsotype analysis of human anti-Borna disease virus antibodies in Japanese psychiatric and general populations.
    Matsunaga, H., Tanaka, S., Fukumori, A., Tomonaga, K., Ikuta, K., Amino, N., and Takeda, M.
    J. Clin. Virol. 43, 317-322, 2008.
  7. An HIV clade B defective particle producing cell line (L-2) shows stability in its HIV mutated genome over 10 years.
    Zhong, Q., Ikuta, K., and Luftig, R. B.
    Current Topics in Virology 6, 15-24, 2008.
  8. Octapeptide repeat region of prion protein (PrP) is required at an early stage for production of abnormal prion protein in PrP-deficient neuronal cell line.
    Sakudo, A., Wu, G., Onodera, T., and Ikuta, K.
    Biochem. Biophys. Res. Commun. 365, 164-169, 2008.
  9. GPI-anchorless human prion protein is secreted and glycosylated but lacks superoxide dismutase activity.
    Sakudo, A., Nakamura, I., Tsuji, S., and Ikuta, K.
    Int. J. Mol. Med. 21, 217-222, 2008.
  10. Normal cytochrome C oxidase activity in prion protein gene-deficient mice.
    Sakudo, A., Taniuchi, Y., Kobayashi, T., Onodera, T., and Ikuta, K.
    Protein Pept. Lett. 15, 250-254, 2008.
  11. Extent of hepatitis E virus elimination is affected by stabilizers present in plasma products and pore size of nanofilters.
    Yunoki, M., Yamamoto, S., Tanaka, H., Nishigaki, H., Tanaka, Y., Nishida, A., Adan-Kubo, J., Tsujikawa, M., Hattori, S., Urayama, T., Yoshikawa, M., Yamamoto, I., Hagiwara, K., and Ikuta, K.
    Vox Sang. 95, 94-100, 2008.
  12. Maturation efficiency of viral glycoproteins in the ER impacts the production of influenza A virus.
    Ueda, M., Yamate, M., Du, A., Daidoji, T., Okuno, Y., Ikuta, K., and Nakaya, T
    Virus. Res. 136, 91-97, 2008.
  13. Reduced incorporation of SARS-CoV spike protein into viral particles due to amino acid substitutions within the receptor binding domain.
    Li, S. M., Li, G. M., Nakamura, S., Ikuta, K., and Nakaya, T.
    Jpn. J. Infect. Dis. 61, 123-127, 2008.
  14. Higher in vitro susceptibility of human T cells to H5N1 than H1N1 influenza viruses.
    Li, Y.-G., Thawatsupha, P., Chittaganpitch, M., Rungrojcharoenkit, K., Li, G.-M., Nakaya, T., Auwanit, W., Ikuta, K., and Sawanpanyalert, P
    Biochem. Biophys. Res. Commun. 371, 484-489, 2008.
  15. Superinfection of defective human immunodeficiency virus type 1 with different subtypes of wild-type virus efficiently produces infectious variants with the initial viral phenotypes by complementation followed by recombination.
    Iwabu, Y., Mizuta, H., Kawase, M., Kameoka, M., Goto, T., and Ikuta, K.
    Microbes Infect. 10, 504-513, 2008.
  16. Inhibitory function of adapter-related protein complex 2 alpha 1 subunit in the process of nuclear translocation of human immunodeficiency virus type 1 genome.
    Kitagawa, Y., Kameoka, M., Shoji-Kawata, S., Iwabu, Y., Mizuta, H., Tokunaga, K., Fujino, M., Natori, Y., Yura, Y., and Ikuta, K.
    Virology 373, 171-180, 2008.
  17. PrPSc level and incubation time in a transgenic mouse model expressing Borna disease virus phosphoprotein after intracerebral prion infection.
    Sakudo, A., Onodera, T., and Ikuta, K.
    Neurosci. Lett. 431, 81-85, 2008.
  18. Borna disease virus RNA detected in Japanese macaques (Macaca fuscata).
    Hagiwara, K., Tsuge, Y., Asakawa, M., Kabaya, H., Okamoto, M., Miyasho, T., Taniyama, H., Ishihara, C., de la Torre, J. C., and Ikuta, K.
    Primates 49, 57-64, 2008.
  19. Prion-removal performance of virus removal filters varies with environmental conditions.
    Yunoki, M., Tanaka, H., Urayama, T., Hattori, S., Ohtani, M., Narita, Y., Kawabata, Y., Miyatake, Y., Nanjo, A., Iwao, E., Morita, M., Wilson, E., MacLean, C., and Ikuta, K.
    Biologicals 36, 27-36, 2008.
  20. Flu pandemic: hte host or the hosting land? (Editorial).
    Ikuta, K., and Ibrahim, M.S.
    Future Virol. 3, 197-201, 2008.
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 2007

  1. Spectroscopic diagnosis of anti-phospholipid antibodies by visible and near-infrared spectroscopy in SLE patient's plasma samples.
    Nojima, J., Sakudo, A., Hakariya, Y., Kuratsune, H., Watanabe, Y., Kanakura, Y., and Ikuta, K.
    Biochem. Biophys. Res. Commun. 362, 522-524, 2007.
  2. Secreted complement regulatory protein clusterin interacts with dengue virus nonstructural protein 1.
    Kurosu, T., Chaichan, P., Yamate, M., Anantapreecha, S., and Ikuta, K.
    Biochm. Biophys. Res. Commun. 362, 1051-1056, 2007.
  3. The RING finger ubiquitin ligase RNF125/TRAC-1 down-modulates HIV-1 replication in primary human peripheral blood mononuclear cells.
    Shoji-Kawata, S., Zhong, Q., Kameoka, M., Iwabu, Y., Sapsutthipas, S., Luftig, R. B., and Ikuta, K.
    Virology 368, 191-204, 2007.
  4. Identification of the suppressive factors for human immunodeficiency virus type-1 replication using the siRNA mini-library directed against host cellular genes.
    Kameoka, M., Kitagawa, Y., Utachee, P., Jinnapat, P., Dhepakson, P., Isarangkura-na-ayuthaya, P., Tokunaga, K., Sato, H., Komano, J., Yamamoto, N., Oguchi, S., Natori, Y., and Ikuta, K.
    Biochem. Biophys. Res. Commun. 359, 729-734, 2007.
  5. Downregulation of an astrocyte-derived inflammatory protein, S100B, reduces vascular inflammatory responses in brains persistently infected with Borna disease virus.
    Ohtaki, N., Kamitani, W., Watanabe, Y., Hayashi, Y., Yanai, H., Ikuta, K., and Tomonaga, K.
    J. Virol. 81, 5940-5948, 2007.
  6. Native state of metals in non-digested tissues by partial least squares regression analysis of visible and near-infrared spectra.
    Sakudo, A., Yoshimura, E., Tsenkova, R., Ikuta, K., and Onodera, T.
    J. Toxicol. Sci. 32, 135-141, 2007.
  7. Neurotoxic prion protein (PrP) fragment 106-126 requires the N-terminal half of the hydrophobic region of PrP in the PrP-deficient neuronal cell line.
    Sakudo, A., Nakamura, I., Lee, D.C., Saeki, K., Ikuta, K., and Onodera, T.
    Protein Pept. Lett. 14, 1-6, 2007.
  8. Novel single nucleotide polymorphisms in the specific protein 1 binding site of the bovine PRNP promoter in Japanese Black cattle: impairment of its promoter activity.
    Nakamura, I., Xue, G., Sakudo, A., Saeki, K., Matsumoto, Y., Ikuta, K., and Onodera, T.
    Intervirology 50, 190-196, 2007.
  9. Distribution and propagation of hepatitis E virus in experimentally infected swine.
    Hagiwara, K., Iwabu, Y., Kanai, Y., Miyasho, T., Daidoji, T., Yunoki, M., Tsujikawa, M., Ohkubo, Y., Yasue, H., and Ikuta, K.
    Open Vet. Sci. J. 1:5-10, 2007.
  10. haracterization of a Borna disease virus field isolates which shows efficient viral propagation and transmissibility.
    Watanabe, Y., Ibrahim, M.S., Hagiwara, K., Okamoto, M., Kamitani, W., Yanai, H., Ohtaki, N., Hayashi, Y., Taniyama, H., Ikuta, K., and Tomonaga, K.
    Microbes Infect. 9, 417-427, 2007.
  11. Aberrant life cycle of human immunodeficiency virus type 1 CRF15_01B-like clinical isolates from Thailand in human CD4+ T-cell lines.
    Warachit, J., Iwabu, Y., Li, Y.-G., Li, G.-M., Isarangkura, P., Ibrahim, M.S., Balachandra, K., Tsuji, S., and Ikuta, K.
    Microbes Infect. 9, 449-459, 2007.
  12. Lipid rafts play an important role in the early stage of severe acute respiratory syndrome-coronavirus life cycle.
    Li, G.-M., Li, Y.-G., Yamate, M., Li, S.-M., and Ikuta, K.
    Microbes Infect. 9, 96-102, 2007.
  13. Variability of parvovirus B19 to inactivation by liquid-heating in plasma products.
    Hattori, S., Yunoki, M., Tsujikawa, M., Urayama, T., Tachibana, Y., Yamamoto, I., and Ikuta, K.
    Vox Sang. 92, 121-124, 2007.
  14. Prion protein gene-deficient cell lines: powerful tools for prion biology (Review).
    Sakudo, A., Onodera, T., and Ikuta, K.
    Microbiol. Immunol. 51, 1-13, 2007.
  15. Recent development in prion disease research: diagnostic tools and in vitro cell culture models (Review).
    Sakudo, A., Nakamura, I., Ikuta, K., and Onodera, T.
    J. Vet. Med. Sci. 69, 329-337, 2007.
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